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Pierce Brosnan's daughter Charlotte has died at the age of just The mother-of-two passed away at her London home on Friday after a three-year battle with ovarian cancer - the same disease which killed her mother Cassandra 22 years ago.

Mr Brosnan said last night: Scroll down for video.

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A young Charlotte with her half-brother Sean being carried and brother Christopher and their parents Pierce and Cassandra in Our hearts are heavy with the loss of our beautiful dear girl. We thank everyone for their heartfelt condolences. The Irish actor reportedly flew back from Eastern Europe, where he has been filming spy thriller November Man, to the UK to be at his daughter's bedside. Charlotte, who was adopted by the actor after he married her mother, leaves behind her husband, artist Alex Smith, and children Isabella, 15, and eight-year-old Lucas.

She is also survived by her brothers Christopher, Sean, Dylan and Paris.

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Hereditary cancers came to prominence earlier this year when Angelina Jolie announced that she had undergone a double mastectomy after discovering that she had faulty genes which made it much more likely that she would develop breast or ovarian cancer.

According to a friend who attended the ceremony, Charlotte and Alex's wedding was a day of celebration.

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Charlotte, left, with her daughter Isabelle, being held by her brother Christopher in Charlotte attending a wedding in with her husband, daughter Isabella, who acted as a bridesmaid at the wedding, and brother. Ovarian cancer is the fifth most common cancer in women in the UK, with the lifetime risk of a woman developing it being about two per cent. Over 80 per cent of women diagnosed with ovarian cancer are over 50, though it can occur in younger women.

The risk of cancer is increased for some women with a strong family history. Dylan lucas bradley huds slams alex waters who have one first-degree relative with breast cancer, diagnosed under the age of 40 or two first or second-degree relatives with breast cancer diagnosed over the age of 50, also have a slightly increased risk.

Rarely, one of these genetic mutations runs in a family, and members of the family who inherit the gene have an increased risk of these cancers. However it is actually quite rare to develop cancer because of an inherited faulty gene, with only 5—10 per cent of cancers thought to be linked to one. Charlotte and her brother Christopher, from Cassandra's previous marriage to Dermot, were joined by a half-sibling Sean in Although Pierce and Charlotte were not biologically related, he has previously spoken of the close relationship he enjoyed with her and her brother after he married Cassandra.

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Charlotte and Chris have just been amazing in my life. Mr Brosnan adopted his wife's children after their biological father Dermot Harris died inand they changed their surname to his. Cassandra became ill while filming in India in and after being diagnosed with ovarian cancer, fought a four-year battle with the disease.

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She was just 43 when she died in Los Angeles in December Over 80 per cent of women diagnosed with ovarian cancer are over 50, though it can also occur in younger women. But the risk of cancer is increased for some women with a strong family history. Dylan lucas bradley huds slams alex waters, it is actually quite rare to develop cancer because of an inherited faulty gene, with only 5—10 per cent of cancers thought to be linked to one.

Around 20 per cent of female population carry a gene that can predispose them to ovarian cancer - and half of them do not have any family history of the disease, Professor Hani Gabra, Director of the Ovarian Cancer Action Research Centre in London, told MailOnline. Charlotte Brosnan and her artist boyfriend Alex Smith are said to have wed just two weeks before her tragic passing. When Hollywood megastar Miss Jolie discovered that she was carrying a faulty version of the BRCA1 gene, she opted to undergo a double mastectomy to minimise her risk of contracting breast cancer.

The Tomb Raider actress went public with her health struggles earlier this year in a bid to encourage women to get themselves tested for genetic defects.

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In an interview with the Mail on Sunday in March, Mr Brosnan spoke about drawing on his own family's experiences in order to play a widower who falls in love with a cancer sufferer in his latest film Love Is All You Need. Pierce and Cassandra's youngest son Sean was only eight years old when she died.

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He told the MoS: Pierce with late wife Cassandra in February - just 10 months before she died. Pierce, Charlotte, Sean and Christopher in following Cassandra's death.

Three years following Cassandra's death, Pierce met journalist Keely Shaye Smith, who he went on to marry in They have two sons together - year-old Dylan and Paris, In the interview, Pierce added: Ups and downs are what life is all about.

But the memory of Cassie and her fight against cancer is never forgotten. Charlotte battled drug dependency and depression in her early thirties and volunteered for treatment at the Priory Clinic in She had previously been treated there for cocaine addiction, and her brother Christopher had received similar therapy for drink and Dylan lucas bradley huds slams alex waters addictions. The Bond actor at the first ever showing of Goldeneye inwith children Christopher, Sean and Charlotte and his second wife Keeley.

Charlotte with her brothers, father and grandmother May at The Matador after-party in London in The dangers posed by hereditary cancers Dylan lucas bradley huds slams alex waters widely publicised earlier this year thanks to the efforts of Hollywood superstar Angelina Jolie.

The year-old actress revealed in May that she had been diagnosed with a faulty version of the BRCA1 gene, which made her highly susceptible to breast and ovarian cancer.

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Both her mother and her grandmother died of ovarian cancer, at the ages of 56 and 45 respectively, while her mother also suffered from breast cancer. Miss Jolie therefore decided to undergo a double mastectomy and reconstructive surgery to minimise her chances of developing the illness. She first went under the knife in February, and had her final round of surgery in April. Dylan lucas bradley huds slams alex waters star went public with her decision in May, saying that she wanted to encourage women to get tested for the defective gene so that they could take preventive action if necessary.

Many celebrities took to Twitter to offer their condolences. Please join us in sending love, prayers and sympathy to Pierce Brosnan and his family for the death of his daughter Charlotte. TV presenter Eamonn Holmes said on Twitter: Thoughts and prayers to the family.

He's had more than his share of sadness. License To Kill actor Robert Davi said: Miles Anthony, agent for Ms Brosnan's brother Sean, said: Charlotte was nine years old when her mother Cassandra married Pierce at Chelsea registry office in Mr Brosnan attending a polo match with Christopher, Cassandra and Charlotte. The family would be split when Cassandra died of ovarian cancer in aged Annwen Jones of Target Ovarian Cancer paid tribute to Ms Brosnan, and called for women to be aware of the risk of hereditary cancers.

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Pierce said his second wife Keely Shaye Smith had been supportive of honouring Cassandra's memory. The views Dylan lucas bradley huds slams alex waters in the contents above are those of our users and do not necessarily reflect the views of MailOnline. Pierce Brosnan devastated after daughter Charlotte, 42, loses battle with ovarian cancer that killed her mother at the same age Charlotte Brosnan died of ovarian cancer in London on Friday, aged 42 Her mother Cassandra died of the same disease in when she was 43 Bond star Pierce flew back from filming to be by his daughter's bedside ' Our hearts are heavy with the loss of our beautiful dear girl,' he says Charlotte is survived by her husband and two children, aged 15 and 8 Ovarian cancer can be hereditary caused by faults in the BRCA genes By Emily Sheridan and Emily Davies and Emine Sinmaz for the Daily Mail Published: Share this article Share.

Charlotte and her brother Chris in Dylan lucas bradley huds slams alex waters Pierce and Charlotte in Edinburgh in Pierce, Charlotte, Sean and Christopher in following Cassandra's death Three years following Cassandra's death, Pierce met journalist Keely Shaye Smith, who he went on to marry in Share or comment on this article: Pierce Brosnan's daughter Charlotte, 42, loses battle with ovarian cancer e-mail. Most watched News videos Cops draw guns on black man picking up trash on his property LaToya Jackson alleges Michael Jackson is guilty back in Incredible moment brown snake eats python which was eating a rat Amber Rudd refers to Diane Abbott as a 'coloured woman' Pet owl asserts his authority and kicks the cat off the sofa Young hooded thugs ambush and chase lone cyclist in Manchester Shoppers confront guard who told blind man with a guide dog to leave Groom impulsively topples food laden table during ceremonial lunch Police appeals to catch group who attacked pensioners with a knife Shocking moment cop shoots driver while clinging to hood Child is left in hysterics as he imitates his dad's northern accent Woman stands up to Amber Rudd's remark on skin colour.

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